Mitofusin 2 acts as a lock and key between vital cellular functions
"Our extensive research found ERMIN2 and ERMIT2 proteins in a wide range of human cells and tissues, including adipose tissue, muscle and liver. These findings stress the involvement of these proteins in the maintenance of optimal cell functionality", explains Antonio Zorzano, professor at the Department of Biochemistry and Molecular Biomedicine at the UB Faculty of Biology and head of the Complex Metabolic Diseases and Mitochondria Lab at IRB Barcelona.
"This study represents one of the few cases in which these alternative variants of mitochondrial proteins have been observed. Consequently, the interaction and mechanism of action we describe in this study are very innovative", says researcher Deborah Naón. The study, which may open up new avenues of study in the field of neurodegenerative diseases, also involves the participation of professors Manuel Palacín and Modesto Orozco, from the Department of Biochemistry and Molecular Biomedicine and IRB Barcelona.