A study published in "Nature" reinforces the contribution of kinease S6K1 in obesity and ageing
Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona George Thomas, from the Department of Physiological Sciences, and Head of the Research Group on Metabolism and Cancer; and Sara Kozma, published an article in the journal Nature about the role of the S6K1 kinase in re-directing the function of glutamyl-prolyl tRNA synthease (EPRS) from translation inhibitor to transporter of fatty acids. The study could potentially lead to the development of biomarkers and therapies to treat obesity and ageing.
Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona George Thomas, from the Department of Physiological Sciences, and Head of the Research Group on Metabolism and Cancer; and Sara Kozma, published an article in the journal Nature about the role of the S6K1 kinase in re-directing the function of glutamyl-prolyl tRNA synthease (EPRS) from translation inhibitor to transporter of fatty acids. The study could potentially lead to the development of biomarkers and therapies to treat obesity and ageing.
Article reference
A. Arif, F. Terenzi, A. A. Potdar, J. Jia, J. Sacks, A. China, D. Halawani, K. Vasu, X. Li, J. M. Brown, J. Chen, S. C. Kozma, G. Thomas, P. L. Fox. «EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice». Nature, February, 2017. DOI: 10.1038/nature2138